Histomorphometric and histologic evaluation of the effects of leukocyte platelet-rich fibrin (L-PRF) and nano-hydroxyapatite (nHA) on bone regeneration in rabbits
- سال انتشار: 1402
- محل انتشار: مجله مواد و تکنیک های دندانپزشکی، دوره: 12، شماره: 1
- کد COI اختصاصی: JR_JDMT-12-1_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 149
نویسندگان
Department of periodontics, College of Dentistry, Shahed University, Tehran, Iran.
Department of periodontics, College of Dentistry, Islamic Azad University, Tehran, Iran.
Department of periodontics, College of Dentistry, Shahed University, Tehran, Iran.
Department of Oral Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Genetics, Iranian National Center for Addiction Studies (INCAS), Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.
Dentist.
Department of periodontics, College of Dentistry, Shahed University, Tehran, Iran.
چکیده
Introduction: The study aimed to assess the histologic and histomorphometric effects of leukocyte platelet-rich fibrin (L-PRF) and nano-hydroxyapatite (nHA) on the regeneration of calvarial bone defects in rabbits.Methods: Four defects were created in the calvaria bone of ۱۴ New Zealand rabbits and filled with L-PRF clot, nHA, or a combination of L-PRF and nHA. The fourth defect remained unfilled to serve as the control group. The rabbits were sacrificed either at ۴ or at ۸ weeks, and the specimens were evaluated for the type and degree of inflammation, foreign body reaction, new bone formation, and residual biomaterial particles.Results: The histomorphometric analysis revealed that L-PRF significantly enhanced osteogenesis (P< ۰.۰۵), and the number of subsequent remnant bodies in the L-PRF group was not significantly different from the control group (P> ۰.۰۵). The results of the histologic analysis showed that the frequency of central bone regeneration significantly increased in prolonged periods (P< ۰.۰۵). There was no significant difference in the utilized biomaterials concerning subsequent bleeding, inflammation, foreign body reaction, and lateral bone regeneration between ۴ and ۸ weeks of treatment (P> ۰.۰۵).Conclusion: The results showed that L-PRF was a suitable option for the induction of bone regeneration with fewer remnant bodies. However, future clinical studies are required to assess the efficacy of these biomaterials in the clinical setting. (J Dent Mater Tech ۲۰۲۳;۱۲(۱): ۴۳-۵۰)کلیدواژه ها
bone regeneration, leukocyte platelet-rich fibrin, Nano-hydroxyapatiteاطلاعات بیشتر در مورد COI
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