Antibacterial and antioxidant activity of catechin, gallic acid, and epigallocatechin-۳-gallate: focus on nanoformulations

  • سال انتشار: 1402
  • محل انتشار: مجله تحقیقات سلولی، مولکولی و زیست پزشکی، دوره: 3، شماره: 2
  • کد COI اختصاصی: JR_CMBR-3-2_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 315
دانلود فایل این مقاله

نویسندگان

Mehran Alavi

Department of Biological Sciences, Faculty of Science, University of Kurdistan, Kurdistan, Sanandaj, Iran Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Michael Hamblin

Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, ۲۰۲۸, South Africa Wellman Centre for Photomedicine, Massachusetts General Hospital, Boston, MA ۰۲۱۱۴, USA Department of Dermatology, Harvard

Ermia Aghaie

High Performance Powertrain Materials Laboratory, School of Engineering, University of British Columbia – Okanagan, Kelowna, V۱V ۱V۷, Canada

Seyed Ali Reza Mousavi

Department of Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA ۹۲۰۳۷; Howard Hughes Medical Institute, The Scripps Research Institute, La Jolla, CA ۹۲۰۳۷

Mohammad Hajimolaali

Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

چکیده

There are up to one million secondary metabolites found in plant species, some of which may have desirable therapeutic activities. Among these secondary metabolites, catechin, gallic acid, and epigallocatechin-۳-gallate are natural phenolic compounds with promising antioxidant and antibacterial activity. However, these compounds have disadvantages of poor solubility and low bioavailability in physiological conditions, along with side effects in patients. Therefore new strategies could rely on formulations with other synthetic and natural materials. Nanoformulations of secondary metabolites could be new efficient strategies to treat many chronic bacterial infections. Combinations and conjugates of catechin, gallic acid, and epigallocatechin-۳-gallate with various antibiotics could reduce the dose of these compounds, increase their antibacterial activity, and decrease cytotoxicity against healthy cells. For instance, a smart combination of two or more secondary metabolites may improve therapeutic applications in physiological conditions. In this regard, the growth of antibiotic-resistant bacteria, specifically multidrug-resistant bacteria with overexpression of efflux pumps and expression of the penicillinase enzyme, has been inhibited significantly. According to recent investigations, this review will discuss the advances and challenges of new micro and nanoformulations of these natural products.

کلیدواژه ها

Secondary metabolites, Natural phenolic compounds, Low bioavailability, Antibacterial Activity, Nanomaterials, Combination therapy

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.