Investigating the Potential Role of piRNAs in Male Infertility
- سال انتشار: 1397
- محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 5، شماره: 3
- کد COI اختصاصی: JR_JIML-5-3_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 150
نویسندگان
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abortion Research Center, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Hematology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده
Infertility is a reproductive-related disorder and different factors account for its development. Male factors contribute to at least ۲۰% of infertility. Despite the efforts performed in this field, the causes often remain idiopathic. Epigenetic factors such as small non-coding RNAs play important functions in male infertility. Also, P-element induced wimpy testis in drosophila-interacting RNAs, as a class of sncRNAs, are involved in spermatogenesis. Therefore, they can be used as a novel and promising approach in the diagnosis, treatment, and prognosis of male infertility. However, this still requires further investigations. This is one of the first studies that reviewed recent investigations on the potential role of piRNAs in male infertility and in human population and can help to better understanding of the etiology of these conditions and diagnosis of patients.کلیدواژه ها
Male infertility, Epigenetic, piRNAs, Small non-coding RNA, ناباروری, ناباروری مردانه, اپی ژنتیک, piRNA, RNA های غیر کدکنندهاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.