Expression Profiles of miR-۹۳ and miR-۳۳۰ in Iranian Patients with Chronic Lymphocytic Leukemia
- سال انتشار: 1398
- محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 6، شماره: 2
- کد COI اختصاصی: JR_JIML-6-2_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 212
نویسندگان
Department of Biochemistry, Faculty of Science, Nourdanesh Institutions of Higher Education, Meimeh, Isfahan, Iran
Young Researchers and Elite Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-۹۳ (miR-۹۳) and microRNA-۳۳۰ (miR-۳۳۰) have been changed in several cancers, including lung, prostate, and colon cancer. We aimed to elucidate the changes in miR-۹۳ and miR-۳۳۰ expression in CLL patients in comparison with controls. Materials and Methods: In this case-control study, the expression levels of miR-۹۳ and miR-۳۳۰ was evaluated in ۳۰ CLL patients who had referred to Omid Hospital, Isfahan, Iran, and ۳۰ controls in peripheral blood mononuclear cells using reverse transcription quantitative PCR (RT-qPCR). Results: The expression of miR-۹۳ and miR-۳۳۰ were found to significantly increase in CLL patients compared with controls (p< ۰.۰۰۰۱). Conclusions: The findings indicated that miR-۹۳ and miR-۳۳۰ are probably the novel potential biomarker for early diagnosis of CLL, at least in Iranian patients. However, for a decisive result, further investigations are warranted.کلیدواژه ها
Chronic lymphocytic leukemia, microRNA, miR-۹۳, miR-۳۳۰, --اطلاعات بیشتر در مورد COI
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