The Effects of Atorvastatin Consumption on Biochemical Variables in Patients with Type ۲ Diabetes Mellitus and Pre-diabetes
- سال انتشار: 1401
- محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 9، شماره: 3
- کد COI اختصاصی: JR_JIML-9-3_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 197
نویسندگان
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran ۲ Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, IRAN
Department of Internal Medicine, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Department of Statistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
چکیده
Background and Aims: Atorvastatin may alter glycemic traits and lipid profiles. This study aimed to evaluate the effects of atorvastatin on biochemical variables in patients with type ۲ diabetes and pre-diabetes (borderline diabetes). Materials and Methods: This study included ۸۰ individuals divided into five groups. Patients with type ۲ diabetes mellitus and pre-diabetes used atorvastatin ۲۰ mg/day for three months. After three months, variables such as serum fasting blood glucose (FBS), cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and glycosylated hemoglobin (HbA۱c) levels were measured to assess the status of diabetes and pre-diabetes condition. Linear regression was applied to determine the association between atorvastatin uses and alters of biochemical variables levels. Results: The serum FBS and HbA۱c levels in patients with diabetes and pre-diabetes who use atorvastatin were significantly lower than in patients with diabetes and pre-diabetes who did not use atorvastatin (p=۰.۰۰۱). Serum cholesterol and LDL-C levels decreased in diabetic and pre-diabetic patients who used atorvastatin in comparison with diabetic and pre-diabetic patients who did not use atorvastatin (p=۰.۰۰۱). In patients with pre-diabetes, the use of atorvastatin slightly increased serum HDL-C levels. However, in patients with diabetes, the use of atorvastatin slightly decreased serum HDL-C level (p= ۰.۰۰۱). Diabetic and pre-diabetic patients who use atorvastatin significantly decreased serum triglyceride levels (p=۰.۰۱۶), while in diabetic and pre-diabetic patients, using atorvastatin slightly increased the serum insulin level (p= ۰.۰۰۳). Conclusions: Atorvastatin using alters fat and sugar indices in diabetic and pre-diabetic patients.کلیدواژه ها
Atorvastatin, Diabetes, HDL-C, LDL-C, Pre-diabetesاطلاعات بیشتر در مورد COI
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