Emergence of OXA-۱۰ and OXA-۴۸ Like Carbapenemases among Enterobacter Isolates from Inpatients in Namazi Hospital in Shiraz
- سال انتشار: 1401
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 8، شماره: 3
- کد COI اختصاصی: JR_IEM-8-3_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 139
نویسندگان
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
۲. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ۱.Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Backgrounds: The global spread of carbapenemase-producing Enterobacteriaceae represents a public health concern. This study aimed to investigate the prevalence of carbapenem resistance and the presence of some oxacillinase types and class ۱-۳ integrons among Enterobacter clinical isolates from an Iranian inpatient population. Materials & Methods: Ninety Enterobacter isolates from hospitalized patients were diagnosed by microbiological methods. Antibiogram pattern was also determined. The presence of class ۱-۳ integrons and four types of oxacillinase genes was assessed using PCR. Findings: Among ۹۰ Enterobacter isolates, the most common species was E. aerogenes, (۴۵.۶%), followed by E. cloacae (۳۰%). The highest resistance rate was against ampicillin (۹۶.۷%). Multi-drug resistance (MDR) was substantial (۹۳%). Carbapenemase-producers were detected in ۹۶% of carbapenem-resistant isolates by mCIM test. The frequency of evaluated genes was as follows: intI۱ = ۵۰ (۵۵.۶%), intI۲ =۱۲ (۱۳.۳%), blaoxa-۱ =۶ (۶.۷%), blaoxa-۲ =۵ (۵.۶%), blaoxa-۱۰ =۱۸ (۲۰%), and blaoxa-۴۸ =۱۸ (۲۰%). Conclusion: Determinants of class ۱ integron along with OXA-۱۰ and OXA-۴۸ like carbapememases are responsible for relatively considerable carbapenem resistance among isolates. This is the first report about the presence of OXA-۱۰ and OXA-۴۸-producing Enterobacter spp. in Iran, indicating that the prevalence of oxacillinases in the country might be on the rise.کلیدواژه ها
Enterobacter, Carbapenemase, Oxacillinase, Integron, Iranاطلاعات بیشتر در مورد COI
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