Arman Dehghani-Talgerdouie - IAU, Yazd branch
Ali Sheibani - IAU, Yazd branch
M. Reza Shishehbore - IAU, Yazd branch

Clopidogrel with trade name plavix, is used effectively to reduce the incidence of ischaemic strokes, heart attacks and claudication. In this study, an ion mobility spectrometry (IMS) method was proposed for the clopidogrel determination in analytical and bio-analytical fields. Under experimental conditions, the analytical validation parameters of the proposed method were calculated and reported. The calibration graph was linear in range ۳۰.۰–۲۰۰۰.۰ µg mL-۱ for clopidogrel with two orders of magnitude and a goodness of fit, R > ۰.۹۹. The coefficient of variation (precision, n=۱۰) was found to be within ۷.۵–۸.۶%, and also the concentration levels of ۳.۰ and ۱۰.۰ µg mL-۱ from analyte were obtained for the limits of detection and quantification, respectively. The developed IMS method was successfully applied to determine clopidogrel with accurate recovery range (۹۰.۰–۱۰۳.۷%) in different matrices. The validation studies showed that the applied IMS was a simple, rapid, sensitive and reliable method for the clopidogrel analysis in the pharmaceutical and biological samples.

Ion mobility spectrometry (IMS), Clopidogrel, Plavix, Pharmaceutical samples, biological samples