Silica-Coated Magnetic Tragacanth Gum Nanoparticles Crosslinked with Citric Acid for the Loading and Delivery of Ranitidine

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 122

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شناسه ملی سند علمی:

JR_ANALCH-10-1_010

تاریخ نمایه سازی: 12 بهمن 1401

چکیده مقاله:

A new magnetic nanocomposite was prepared by synthesizing Fe۳O۴@SiO۲ nanoparticles and then coating them with a shell of tragacanth gum (TG) as a natural product modified by citric acid (CA). The obtained Fe۳O۴@SiO۲@TG@CA nanoparticles were identified by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX) and Fourier transform infrared spectroscopy (FT-IR). The prepared magnetic nanoparticles were used for loading and delivery of ranitidine, an oral drug. Conditions for drug loading were optimized by a central composite design optimization method. The maximum loading efficiency for ranitidine was ۷۹.۳% that was obtained at pH ۱۱ and its in vitro release was gained within ۵۵ min at pH ۱.۶ in a phosphate buffer medium. The loading capacity of the nanocarrier was dependent on the initial concentration of ranitidine and exceeded ۱۱.۴ mg g-۱ in a solution of ۲۰۰ mg L-۱. The study of adsorption isotherms to describe the interaction of ranitidine with the carrier showed the best fit with Freundlich isotherm. The results showed that the prepared Fe۳O۴@SiO۲@TG@CA adsorbent, as a non-toxic and low-cost nanocarrier, is quite suitable for drug delivery applications.

نویسندگان

Fereshteh Farajian

Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, I.R. Iran

Payman Hashemi

Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, I.R. Iran