The Histopathological Evaluation of the Effects of Capparis spinosa Seed Hydroalcoholic Extract on Cisplatin- induced-Nephrotoxicity in Rats
- سال انتشار: 1401
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 31، شماره: 144
- کد COI اختصاصی: JR_ZUMS-31-144_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 158
نویسندگان
Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Dept. of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Dept. of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Dept. of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
چکیده
Background and Objective: Increment in cancer prevalence and subsequent need for chemotherapy leads to distinct kidney-related diseases such as acute kidney injury (AKI). Cisplatin is a common chemotherapeutic agent that has been used in many cancers; however, it can damage renal cells. Capparis spinosa is an important therapeutic plant in Persian medicine that encompasses high amounts of bioactive antioxidant components. The current study aimed to evaluate the nephroprotective effects of Capparis spinosa seed hydroalcoholic extract (CSSE) against cisplatin-induced nephrotoxicity in vivo through histopathological evaluation. Materials and Methods: Forty Sprague Dawley rats weighing within the range of ۲۳۰±۲۰ gr were randomly divided into eight groups including sham, a single-dose cisplatin intraperitoneally (IP) injected group (۷ mg/kg), toxic dose CSSE (۲۰۰ mg/kg) group, and groups with cisplatin ۷mg/kg IP and different doses of CSSE. Histopathological changes in the kidney tissues were quantified by the image-J program and analyzed by statistical methods. Results: Cisplatin-induced glomerular and tubular injuries in the kidney tissue. A single-dose cisplatin decreased the glomerular area and Bowman's capsule area, increased Bowman's space, and induced tubular loss of brush borders, tubular dilatation, tubular cast formation and tubular necrosis. All of the changes were reversed by CSSE significantly. Conclusion: Post-CSSE (۵۰ and ۱۰۰ mg/kg) treatment could protect against cisplatin-induced nephrotoxicity in vivo. More clinical studies are needed to confirm its protective effects on the prevention of kidney injury in chemotherapy receiving patients.کلیدواژه ها
Capparis spinosa, Persian Medicine, Pathology, Acute kidney injury, Cisplatin. Cancerاطلاعات بیشتر در مورد COI
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