Effects of ۸ Weeks Resistance Training on the Expression of MicroRNAs Associated With Adipose Tissue Angiogenesis in Rats on a High-Fat Diet
- سال انتشار: 1401
- محل انتشار: مجله کشت ها و گردش خون، دوره: 3، شماره: 1
- کد COI اختصاصی: JR_QJVC-3-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 130
نویسندگان
Department of Sports Science, Faculty of Literature and Humanities, University of Qom, Qom, Iran
Department of Sports Physiology, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Department of Sports Science, Faculty of Literature and Humanities, University of Qom, Qom, Iran
Department of Sports Physiology, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
چکیده
Background and Aim: Recent research has shown that microRNAs (miRNAs) can be regarded as new biomarkers for metabolic and angiogenesis-related diseases. This study aimed to investigate the effect of ۸ weeks of resistance training on the expression of miRNAs associated with adipose tissue angiogenesis in rats with a high-fat diet. Materials and Methods: Forty male Wistar rats were randomly divided into four groups (each with ۱۰ rats): normal diet, normal diet+resistance training, high-fat diet, and high-fat diet+resistance training. The resistance training groups performed ۵ sessions of resistance training protocol each week for ۸ weeks. After one week of familiarity with ladders, in the ۲nd week, weights of ۳۰% of body weight were attached to the rats’ tails, which gradually reached about ۱۸۰% of their body weight by the end of ۸ weeks. To evaluate the effect of resistance training and a high-fat diet on miR-۲۲۱, miR-۲۲۲, miR-۳۲۹, and vascular endothelial growth factor (VEGF) variables, sampling of mesenteric adipose tissue was performed immediately after killing the animals. Results: The levels of miR-۲۲۱, miR-۲۲۲, and VEGF in the resistance training group+normal diet and resistance training group+high-fat diet increased significantly compared to the control groups (P=۰.۰۰۱, and P=۰.۰۰۱, respectively). However, no significant difference was observed in any groups regarding miR-۳۲۹ (P=۰.۱۰۳). Conclusion: The results showed that resistance training increased microRNAs levels associated with adipose tissue angiogenesis in rats on a high-fat and normal diet.کلیدواژه ها
High-fat diet, Angiogenesis, MicroRNAs, Resistance trainingاطلاعات بیشتر در مورد COI
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