Comparison between viral vector and mRNA based COVID-۱۹ vaccination in prevalence and severity of regional immune reactions, and ۱۸F-FDG PET/CT features

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 108

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شناسه ملی سند علمی:

JR_JNMB-11-1_002

تاریخ نمایه سازی: 25 دی 1401

چکیده مقاله:

Objective(s): The coronavirus pandemic caused by SARS-CoV-۲ commenced in late ۲۰۱۹, and global wide vaccination appears to be the only reasonable solution to fight this dreadful virus. There are two main types of COVID-۱۹ immunization using viral vector and mRNA-based vaccines. However, the impact of each of type on ۱۸F-FDG PET/CT needs to be accurately assessed. This study aimed to compare the ۱۸F-FDG PET/CT features of these two types of COVID-۱۹ vaccines.Methods: A total of ۱۸۸ patients referred for ۱۸F-FDG PET/CT with a recent history of either BioNTech/Pfizer or AstraZeneca COVID-۱۹ vaccination, and a control group of ۴۰ patients with no history of any type of recent vaccination, were included in the study. ۱۸F-FDG PET/CT studies of vaccinated patients assessed for injection site uptake and regional nodal and systemic reactions post vaccination. The data were compared to the control group and to the contralateral side for each patient. The findings were compared between patients who received Pfizer and AstraZeneca vaccines.Results: ۱۸F-FDG PET/CT was semiquantitatively positive in ۵۰.۵% of the studied population for vaccine-related features. The ipsilateral axillary and infra- and supraclavicular lymph nodes were significantly larger in size and exhibited higher metabolic activity compared to the contralateral lymph nodes after both types of vaccination. The prevalence of regional nodal reactions post Pfizer and AstraZeneca vaccination was ۳۹% and ۱۷.۹% on visual, and ۶۱% and ۴۷.۶% on semiquantitative assessments, respectively. Patients receiving the Pfizer vaccine exhibited higher metabolic activity in the ipsilateral regional lymph nodes (p<۰.۰۵). No significant difference in the intensity of regional nodal reaction post vaccination was noted between the first four weeks.Conclusion: Significant local and regional nodal reactions are observed after both viral vector and mRNA COVID-۱۹ vaccination with a tendency to extend toward the infra- and supraclavicular nodal stations but not to the pulmonary hilum. The greater intensity and extension of the nodal reaction after Pfizer vaccination suggests a higher possibility of false-positive results on ۱۸F-FDG PET/CT studies using mRNA vaccination technology.

نویسندگان

Narjess Ayati

Department of Nuclear Medicine, Ultrasound & PET, Westmead Hospital, NSW, Australia

Scott Evans

Department of Nuclear Medicine, Ultrasound & PET, Westmead Hospital, NSW, Australia

Seyed Rasoul Zakavi

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Simon Gruenewald

Department of Nuclear Medicine, Ultrasound & PET, Westmead Hospital, NSW, Australia

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