Histomorphometric Study Based on Personal Medicine Effect of Propiconazole on Bone Growth Plate of Male Gerbil

  • سال انتشار: 1401
  • محل انتشار: فصلنامه پزشکی شخصی، دوره: 7، شماره: 27
  • کد COI اختصاصی: JR_PMJ-7-27_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 180
دانلود فایل این مقاله

نویسندگان

Saber Kabiri-Samani

Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Hamidreza Kabiri

Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran; Sina Borna Aria (SABA) Co., Ltd, Research and Development Center for Biotechnology, Shahrekord, Iran.

چکیده

Propiconazole is a systemic fungicide from the triazole group used to control a wide range of diseases. This poison causes cellular, genetic and metabolic damage in animals. A bone is a hard tissue whose content is constantly changing. Longitudinal growth of the bone occurs through the growth plate, which is a cartilaginous structure at the end of the body's long bones. During puberty, while the growth plate closes (ossifies), the longitudinal growth of the bone stops. This study aimed to investigate propiconazole's effect on growth plate width changes (including the area of ​​proliferating cells and the area of ​​hypertrophied cells) in immature rats. This experimental study was conducted on ۱۲ immature male Wistar rats randomly divided into control and propiconazole groups. The treatments were done by oral gavage for ۲۸ days. On the ۲۸th day, the dead animals and the left leg femur were separated for histomorphometric studies of the growth plate width of the femoral epiphysis. Investigations were carried out by (Rasband Wayne, ۴۰g.۱. ver, ImageJ, USA, NIH), and the significance of the results was done by ANOVA analysis of variance and Tukey's test. The width of the growth plate in the propiconazole group had a significant decrease compared to the control group (P = ۰.۰۱۲۶), which is a decrease in the width of the proliferating area (P < ۰.۰۰۱) and an increase in the width of the hypertrophied area (P = ۰.۰۱۶). Propiconazole leads to a decrease in the width of the growth plate of the femoral epiphysis of immature rats. It can be a factor in disrupting the process of longitudinal bone growth and premature closure of the growth plate.

کلیدواژه ها

Growth plate, Bone tissue, Propiconazole, Oxidative stress, Rat

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.