A Survey to Compare the Efficacy of Niosomal Erythromycin Alone versus Combination of Erythromycin and Zinc Acetate in the Treatment of Acne Vulgaris

  • سال انتشار: 1396
  • محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 24، شماره: 5
  • کد COI اختصاصی: JR_JKMU-24-5_008
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 101
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نویسندگان

Saman Mohammadi

Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran

Saeedeh Farajzadeh

Professor of dermatology, Leishmaniasis Research Center, Kerman University of Medical Sciences, Iran

Abbas Pardakhti

Professor of Pharmaceutics, Neuropharmacology Institute, Pharmaceutics Research Center, Kerman University of Medical Sciences, Kerman, Iran

Maryam khalili

Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran

Azadeh Mohebbi

Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran

Mohammad Reza Yousefian

Resident of dermatology, Kerman University of Medical Sciences, Iran

Mahin Aflatoonian

Assistant professor of dermatology, Department of Dermatology, Kerman University of Medical Sciences, Iran

چکیده

Background: Acne vulgaris is one of the most common inflammatory skin diseases. Topical antibiotics and retinoids are the first-line therapy in mild to moderate acne vulgaris. Due to increased resistance of Propionibacterium acnes (P. acnes) to topical antibiotics, searching for new formulations of drug release such as niosomes is considered in order to increase efficacy and decrease drug resistance. This study compared the efficacy of niosomal erythromycin۴% versus combination of erythromycin ۴% and zinc acetate ۱.۲% in the treatment of mild to moderate acne vulgaris. Methods: In this double-blind clinical trial, ۷۰ patients with mild to moderate acne vulgaris of both genders aged between ۱۲ to ۳۰ years were included. The patients were evaluated by counting of the lesions and assessment of quality of life during the ۲nd, ۴th, ۸th and ۱۲th weeks. Results: At the end of the study, ۴۰% and ۶۶.۶% of the patients in niosomal erythromycin group showed a reduction in the number of non-inflammatory and inflammatory lesions, respectively. These percent for erythromycin and zinc acetate group were ۴۶.۶% and ۶۳.۳%. One hundred percent of excellent response (۸ out of ۳۰ patients) was observed in niosomal group (P=۰.۰۰۲). A significant improvement in the quality of life was also observed in niosomal group (P=۰.۰۰۱). Side effects were much less severe in the niosomal group than control group. Conclusion: The results showed that niosomal erythromycin has higher efficacy and less severe side effects in comparison with combination of erythromycin and zinc acetate.

کلیدواژه ها

Acne Vulgaris, Niosomal, Erythromycin, Zinc Acetate

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