elham jafari - Assistant Professor, Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
Shariar Dabiri - Professor of Pathology, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Abbas Mortazaeizadeh - Researcher, Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
Ahmad Reza Sayadi - Assistant Professor, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Sahar Amir Poor Rostami - Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than ۱۰۰ types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-۱۶ and HPV-۱۸ have shown further association with cancer. Regarding the presence of E۶ and E۷ in HPV and ability for modification of basal epithelial cells, related role in prostate cancer (as well as cervical and genital malignancies) is hypothesized. The aim of this study was to determine the association of HPV-۱۶ and HPV-۱۸ with prostate cancer and malignancy degree. Methods: A total of ۷۵ consecutive paraffin-embedded blocks including ۵۰ samples with primary prostate cancer and ۲۵ samples with benign prostate hyperplasia (BPH) as control were studied. Amplisense kit was used for replication at real-time polymerase chain reaction (PCR) to determine genotypes of HPV-۱۶ and HPV-۱۸. DNA purity was assessed by Nano Drop. Results: The results of real-time PCR demonstrated that none of the samples of BPH and prostate cancer had amplification of HPV DNA. Conclusion: The results revealed that HPV-۱۶ and HPV-۱۸ are not causes of prostate cancer.

Benign prostate hyperplasia, Prostate carcinoma, Human papilloma virus