Effect of Troxerutin on Oxidative Stress Induced by Sciatic Nerve Ischemia-reperfusion Injury in Rats

  • سال انتشار: 1399
  • محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 27، شماره: 4
  • کد COI اختصاصی: JR_JKMU-27-4_006
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 224
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نویسندگان

Saideh Dadpisheh

M.Sc. of Physiology, Department of Physiology, Iranshahr University of Medical Sciences, Iranshahr, Iran

Hassan Ahmadvand

Professor in Clinical Biochemistry, Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Leila Jafaripour

MSc. of Anatomical Scinces, Department of Anatomy, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran and Department of Anatomical Sciences, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran

Negar Nouryazdan

M.Sc. of Clinical Biochemistry, Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Esmaeel Babaeenezhad

Ph.D. Student in Clinical Biochemistry, Department of Clinical Biochemistry, School of Medicine, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hamzeh Shati

Student of Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

Shahrokh Bagheri

Ph.D. Student in Clinical Biochemistry, Razi Herbal Medicines Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran

چکیده

Background:Troxerutin has antioxidant and anti-inflammatory properties and in this study, its antioxidant effect on the reduction of oxidative stress induced by ischemia-reperfusion sciatic nerve injury was investigated. Methods:In this study, ۶۴ male rats were randomly divided into ۸ groups as follows: ۱- IR۲: ischemia (۳ hours) and reperfusion (۲ days), ۲- Trox+IR۲: ischemia (۳ hours) and reperfusion (۲ days), ۳- IR۷: ischemia (۳ hours) and reperfusion (۷ days), ۴- Trox+IR۷: ischemia (۳ hours) and reperfusion (۷ days), ۵- IR۱۴: ischemia (۳ hours) and reperfusion (۱۴ days), ۶- Trox+IR۱۴: ischemia (۳ hours) and reperfusion (۱۴ days), ۷- IR۲۸: ischemia (۳ hours) and reperfusion (۲۸ days), ۸- Trox+IR۲۸: ischemia (۳ hours) and reperfusion (۲۸ days). The rats received ۱۵۰ mg/kg troxerutin in one injection (single dose). After separation of serum, biochemical parameters of the serums such as NO, PON۱, CAT, and GPX were measured. Results:Troxerutin significantly increased the GPX and PON۱ levels in groups that their reperfusion time was ۲ and ۱۴ days (p < ۰.۰۵). There was no significant difference in the levels of NO and CAT between the groups received troxerutin and control groups (P> ۰.۰۵). Conclusion:Troxerutin relatively decreased the oxidative stress in the sciatic nerve ischemia-reperfusion injury by increasing the level of antioxidant enzymes.

کلیدواژه ها

Troxerutin Sciatic Nerve Ischemia, Reperfusion Rat

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