Antidiabetic and Antioxidant Properties of Sea Urchin Echinometra mathaei from the Persian Gulf

  • سال انتشار: 1400
  • محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 28، شماره: 1
  • کد COI اختصاصی: JR_JKMU-28-1_011
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 332
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نویسندگان

Soolmaz Soleimani

Professor of Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran

Elham Pirmoradloo

Department of Biochemistry, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran

Fatemeh Farmani

Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Soheila Moein

Professor of Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Morteza Yousefzadi

Professor of Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran

چکیده

Background: The aim of the present study was to evaluate the inhibition of α-glucosidase and antioxidant properties of different tissues of sea urchin Echinometra mathaei. Methods: α-glucosidase inhibition was determined using p-Nitrophenyl-a-D-glucopyranoside as a substrate, and the antioxidant properties were evaluated by ۲,۲'-azino-bis (۳-ethylbenzothiazoline-۶-sulfonic acid) (ABTS),۱,۱-diphenyl-۲-picrylhydrazyl (DPPH), and nitric oxide radicals scavenging. Also, antioxidant potential was evaluated by the ferric reducing antioxidant power (FRAP) method. Results: Among the studied tissues, the highest α-glucosidase inhibition was revealed by the ethyl acetate extract of the shell and Aristotle’s lantern (IC۵۰ = ۳.۷ and ۴ mg/mL, respectively). Shell had the highest ABTS (IC۵۰ = ۱۸۳) and DPPH (IC۵۰ = ۲۰۸ μg/mL) radicals scavenging, respectively. And, gonad had the highest antioxidant potential by the FRAP method (۱۱۴۰ μg ASA/mg) and NO radical scavenging (۷۰.۶۸%), respectively. Conclusion: Antidiabetic potentials of the ethyl acetate extracts of sea urchin tissues suggest that these extracts can be used as antidiabetic drugs.

کلیدواژه ها

Antidiabetic, Antioxidant Properties Echinometra mathaei The Persian Gulf

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