Biological Functions of Nitric Oxide in the Brain and Brain Stem
- سال انتشار: 1401
- محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 29، شماره: 6
- کد COI اختصاصی: JR_JKMU-29-6_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 331
نویسندگان
Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Department of Physiology, Medical School, Tarbiat Modares University, Tehran, Iran
Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
چکیده
Nitric oxide (NO) is a small biological arbitrator and signaling molecule that has numerous significant biological roles in our body. Most of the neurons produce NO by neuronal nitric oxide synthase (nNOS). NO has been involved in the regulation of neurogenesis, synaptic plasticity, learning, and memory. Also, it contributes to the regulation of circulation and synapses, cerebral map formation, and neuropeptides. In the current review, we focused on previous research that has demonstrated structural aspects, subcellular localization, and some factors that adjust nNOS function. Furthermore, we have characterized the effect of nNOS in the brain in some physiological situations, particularly long-term potentiation and depression (LTP and LTD) and neural plasticity during development . Moreover, the effect of NO on neuropeptidergic neurons, including orexin, in reward systems was reviewed. Also, this study has focused on the NO involvement in brain circulation, the excitability of neurons, and the homeostatic balance of excitatory and inhibitory signaling in the brain.کلیدواژه ها
Nervous system, nitric oxide, brain, Brain stemاطلاعات بیشتر در مورد COI
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