LGR۵ As A Potential Therapeutic Target for Breas tCancer: A Sys tematic Review and Meta-Analysis

Objective: Since the emergence of precision medicine, the developmentof cancer s tem cells (CSCs) has promoted the implementationof novel patient-centered therapies. Leucine-richrepeat-containing G-protein-coupled receptor ۵ (LGR۵), theso-called GPR۴۹, plays a considerable role in the heterogeneityof tumors such as breas t cancer. Breas t cancer has emerged asthe mos t common malignancy worldwide as of ۲۰۲۱. The implicationof LGR۵ in novel approaches to breas t cancer therapyis a potential landscape for research. We aimed to assess theprevalence, prognos tic, and therapeutic role of LGR۵ in breas tcancer.Materials and Methods: We performed this sys tematic reviewand meta-analysis s tudy using databases including Web of Science,Scopus, and PubMed. We searched these databases usingLGR۵ and Breas t Cancer and related keywords based on theMeSH database until October ۱۲, ۲۰۲۱. All s tudies that reportedthe prevalence of LGR۵ overexpression via Immunohis tochemistry (IHC) in breas t cancer patients were included in thisreview. We applied the S tATA and random effect models fordata analysis.Results: Finally, seven s tudies of ۲۶۳۲ breas t cancer sampleswere reviewed in this s tudy. The pooled prevalence ofLGR۵ high expression in breas t cancer was ۳۶ % (۹۵%CI:۲۶-۴۷.۵%, I۲= ۹۵.۵) and in triple-negative breas t cancer was۴۸.۶% (۹۵%CI: ۳۸.۴-۵۸.۷%, I۲= ۰.۰). There was a s tatis ticalsignificance in the correlation between LGR۵ overexpressionand ER+ breas t cancer patients (pooled OR: ۰.۵۴, ۹۵%CI: ۰.۳۲-۰.۹۲, I۲: ۶۲%). Furthermore, we observed that LGR۵ overexpressionis correlated with TNM s taging of tumors (pooled OR:۵.۰۶, ۹۵%CI: ۲.۶۳-۹.۷۴).Conclusion: In principle, the prevalence of LGR۵ high expressionin breas t cancer particularly triple-negative types wasconsiderable. Hence, we sugges t that LGR۵ can be a potentialtherapeutic target for breas t cancer. The effectiveness of LGR۵in the tailored treatment of breas t cancer needs further inves tigation.

کلیدواژه ها:

Breas t Cancer ، Cancer S tem Cell ، Leucine-Rich Repeat-Containing G-Protein-Coupled Receptor ۵ (LGR۵) ، TailoredMedicine