Fabrication of ۱۰-HDA / Royal Jelly-Containing Liposomesand The Evaluation of Inflammatory Properties

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 75

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شناسه ملی سند علمی:

RROYAN23_260

تاریخ نمایه سازی: 17 دی 1401

چکیده مقاله:

Objective: Liposomes are bilayer Nano vesicles which can trapand hold hydrophilic and hydrophobic subs tances. Similarity tothe cell membrane made liposomes useful in drug delivery. Thistechnique is reducing the dose of drugs and also improves theirefficiency. The human generation are using bee products foryears. Honey is well-known for its effects on the human body.Royal Jelly (RJ), is another bee product that has shown significantantibacterial, anti-inflammatory, and res torative activity.۱۰-HDA (۱۰-hydroxy-۲-decanoic acid) is the active componentin RJ. While the composition of the percentage of royal jellyvaries according to its origin, bee breed, and s torage conditions,۱۰-HDA has a specific chemical s tructure.Materials and Methods: The thin-film hydration method hasbeen chosen for liposome preparation. The shape and s tructureof prepared liposomes were checked by scanning electron microscopy(SEM) and (TEM). Also, liposome surface functionalgroups were analyzed by infrared (IR) spectroscopy. Changesin the hydrophilic radius and surface charge of liposomes wereinves tigated using DLS and Zetasizer. Also, the loading efficiencyand release rate of the liposomes were evaluated by UVVisand fluorescent spectroscopy.Results: In skin diseases infections, inflammation, and the needfor the high permeability of drugs in the skin are important. inthis s tudy, (RJ) has been loaded in Nano liposomes for its antibacterialand anti-inflammatory properties.Conclusion: Based on research and the importance of findingsomething to replace chemical antibiotics, we expect RoyallJelly or ۱۰-HDA can be useful as an organic antibiotic. We hopeour s tudy help to find an organic, non-toxic, and natural substance for replacing chemical antibiotics.

نویسندگان

A Javanmardi Isfahani

Department of Microbiol Biotechnology, Faculty of Science andTechnology, ACECR, Institute of Higher Edication, Isfahan, Iran

SZ Mirahmadi-Zare

Department of Animal Biotechnology, Cell Science ResearchCenter, Royan Ins titute for Biotechnology, ACECR, Isfahan, Iran

N Saneei

Department of Animal Biotechnology, Cell Science ResearchCenter, Royan Ins titute for Biotechnology, ACECR, Isfahan, Iran

N Shafiee

Department of Animal Biotechnology, Cell Science ResearchCenter, Royan Ins titute for Biotechnology, ACECR, Isfahan, Iran