The Altered Expression of Toll-Like Receptors ۲, ۴, NFKBand Trap May be Represent a Possible Molecular Explanationfor Decreased Implantation in Hydrosalpinx Patients
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی هیبریدی پزشکی تولید مثل و هجدهمین کنگره هیبریدی فناوری سلولهای بنیادی رویان
- کد COI اختصاصی: RROYAN23_118
- زبان مقاله: انگلیسی
- تعداد مشاهده: 63
نویسندگان
Department of Cellular and Molecular Biology, University of Scienceand Culture, Tehran, Iran . Department of Endocrinology and Female Infertility, ReproductiveBiomedicine Research Center, Royan Ins titute for ReproductiveBiomedicine, ACECR, Tehran, Iran
Department of Endocrinology and Female Infertility, ReproductiveBiomedicine Research Center, Royan Ins titute for ReproductiveBiomedicine, ACECR, Tehran, Iran . Faculty of Basic Sciences and Advanced Technologies in Biology,Department of Molecular Cell Bi
Department of Endocrinology and Female Infertility, ReproductiveBiomedicine Research Center, Royan Ins titute for ReproductiveBiomedicine, ACECR, Tehran, Iran
Department of Endocrinology and Female Infertility, ReproductiveBiomedicine Research Center, Royan Ins titute for ReproductiveBiomedicine, ACECR, Tehran, Iran
Department of Endocrinology and Female Infertility, ReproductiveBiomedicine Research Center, Royan Ins titute for ReproductiveBiomedicine, ACECR, Tehran, Iran
Advanced Therapy Medicinal Product Technology DevelopmentCenter, Royan Ins titute for S tem cell Biology and Technology, ACECR,Tehran, Iran
چکیده
Background: Infertility is defined as the failure to es tablish aclinical pregnancy after ۱-year regular unprotected sexual intercourse.Tubal disease of the fallopian tubes is one of the majorcauses of female infertility and hydrosalpinx is the mos t severemanifes tation of tubal disease. Hydrosalpinx patients have lowerimplantation and pregnancy rates in Assis ted ReproductiveTechnology (ART), due to a combination of mechanical andchemical factors thought to disrupt the endometrial environment.The response between the immune sys tem and the reproductivesys tem is very important for healthy pregnancy. Tolllikereceptors (TLRs), as a member of innate immune sys tem,activates signaling pathways that elicit effective antimicrobialand inflammatory responses.Materials and Methods: Endometrial tissue includes case andcontrol groups. The case group included women with hydrosalpinx(n = ۱۰) and the control group included women with malefactors (n = ۱۰). In both groups, Q-PCR analysis was used toevaluate the relative expression of TLR ۲, ۴, NFKB and TRAPgenes.Results: The mRNA expression levels of TLR ۲ and ۴ weresignificantly decreased in patients with hydrosalpinx comparedwith control women (P≤۰.۰۵). TRAP gene involved inTLRs signaling pathways was significantly increased; however,NFKB was significantly decreased in endometrial samplesfrom patients with hydrosalpinx compared with control women(P≤۰.۰۵).Conclusion: As the role of the innate immune sys tem in implantationhas been identified, so alteration in the expression ofone of its components, including the Toll-like receptors or theirpathway genes, can disrupt the implantation process in thesepatients.کلیدواژه ها
Hydrosalpinx, Toll-Like Receptors, Inflammatoryاطلاعات بیشتر در مورد COI
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