Protective Effects of Equisetum Arvense MethanolicExtract on Epididymal S tructure in Diabetic Male Mice
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی هیبریدی پزشکی تولید مثل و هجدهمین کنگره هیبریدی فناوری سلولهای بنیادی رویان
- کد COI اختصاصی: RROYAN23_089
- زبان مقاله: انگلیسی
- تعداد مشاهده: 119
نویسندگان
Department of Basic Science, Faculty of Veterinary Medicine, UrmiaUniversity, Urmia, Iran
Department of Basic Science, Faculty of Veterinary Medicine, UrmiaUniversity, Urmia, Iran
Department of Basic Science, Faculty of Veterinary Medicine, UrmiaUniversity, Urmia, Iran
چکیده
Background: Diabetes mellitus is a major metabolic disorderthat has adverse effects on male reproductive sys tem. This diseasediseasedamages the epididymal tissue and leads to male infertility.Recently, herbs have been a popular source of medicine for preventionof diabetes. Thus, the current s tudy aimed to evaluatethe protective effects of Equisetum arvense methanolic extract(EE) on diabetes-induced detrimental effects on his tologicals tructure of epididymis and cauda epidydimal sperm.Materials and Methods: Twenty four mature male mice weredivided equally in four groups: control-sham, diabetic (inducedby s treptozotocin, ۵۰ mg/kg for five days), diabetic+EE (۲۵۰mg/kg, orally, daily gavage) and diabetic+EE (۵۰۰ mg/kg, orally,daily gavage). After ۴۵ days, the animals were euthanized.Then, cauda epididymis was analyzed for his topathological alteration.Also, epididymal sperm were collected to evaluate thesperm characteris tics.Results: Epithelium thickness and diameter of the caudaepididymal tubule and lumen were decreased remarkably(P< ۰.۰۵) in the diabetic group compared with the control-shamgroup, whereas the EE-treatment decreased significantly(P< ۰.۰۵) the adverse effects of diabetes. The percentage ofsperm with abnormal morphology was significantly (P< ۰.۰۵)lower in treated groups than in the diabetic group. Although thesperm count was decreased in diabetic group, it was not s tatisticallysignificant (P> ۰.۰۵) with those in diabetic+EE. Spermmotility and viability were increased significantly (P< ۰.۰۵) inthe treated groups compared with the diabetic group.Conclusion: The EE inhibited diabetes-induced damages onepididymal tissue and sperm quality, which may have been associatedwith hypoglycemic and antioxidative activities in thisplant.کلیدواژه ها
Diabetes, Equisetum Arvense, Epididymis, Spermاطلاعات بیشتر در مورد COI
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