Exercise Training Ameliorates The Sperm Motility byBoos ting β-Defensin Expression and Antioxidant S tatus ofEpididymis after Nandrolone Consumption in Rats
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی هیبریدی پزشکی تولید مثل و هجدهمین کنگره هیبریدی فناوری سلولهای بنیادی رویان
- کد COI اختصاصی: RROYAN23_088
- زبان مقاله: انگلیسی
- تعداد مشاهده: 136
نویسندگان
Department of Exercise Physiology and Corrective Exercises,Faculty of Sport Sciences, Urmia University, Urmia, Iran
Department of Exercise Physiology and Corrective Exercises,Faculty of Sport Sciences, Urmia University, Urmia, Iran
Department of Physiology, Faculty of Medicine, Urmia Universityof Medical Sciences, Urmia, Iran
چکیده
Background: Nandrolone decanoate (ND) adminis trationhas been reported to significantly induce germ cell apoptosis,suppress tes ticular endocrine s tatus, and decrease the spermmorphology and motility ratio. On the other hand, moderateintensityexercise training protocol (MICT) is shown to boos tanti-apoptotic proteins expression, sys temic and tes ticularendocrine s tatuses, and sperm quality. The current s tudy wasaimed to inves tigate the protective effect of MICT on ND-induceddetrimental effects on sperm parameters by exploringpossible changes in β-defensin (۱-۴) expression and tes ticularantioxidant s tatus.Materials and Methods: For this purpose, ۲۴ mature maleWis tar rats were divided into sedentary control, MICT (E-sole),ND-adminis trated (۱۰ mg/kg, ۳ times/week, for ۴۰ days, ip),and E+ND-induced groups. Following ۴۰ days, the tes ticularoxLDL and carbonyl groups (CG, markers for lipid and proteinperoxidation), β-defensins (۱-۴) expression levels, and spermcount, motility, and DNA integrity were examined and comparedbetween groups.Results: Observations revealed that ND could significantly(P< ۰.۰۵) increase tes ticular oxLDL and CG versus control rats.Moreover, it could remarkably (P< ۰.۰۵) suppress the epidydimalβ-defensins (۱-۴) expression and decrease the spermcount, motility, and DNA integrity. However, > > exercise trainingcould diminish tes ticular oxLDL, CG, and boos t β-defensins(۱-۴) expression, and ameliorate sperm count, motility, andDNA integrity (P< ۰.۰۵).Conclusion: Minding that tes ticular antioxidant s tatus cooperateswith β-defensins to protect sperm motility, nuclear maturation,and fertilization potential, we can conclude that exercisecould improve sperm motility and DNA integrity by inhibitingoxidants-induced lipid and protein peroxidation in tes ticles andβ-defensins (۱-۴) expression level in the epididymis.کلیدواژه ها
β-defensin, Exercise Training, Nandrolone Decanoate,Sperm Parametersاطلاعات بیشتر در مورد COI
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