Expanding The Scope of Preimplantation GenomicTes ting in IVF

Recent advances in sequencing technology and “polygenic riskscores” offer the potential to expand the scope of genetic tes tingto conditions that are increasingly relevant to the health ofindividuals and their growing families. We recently describedan approach that combines molecular and s tatis tical techniquesto reliably infer inherited genome sequence in ۱۱۰ embryos.Advantages, challenges and controversies of this approach willbe discussed.