Diet-induced microbiota as a potential option for cancer treatment(Systematic review)

Cancer is the leading cause of death worldwide. Treating cancer has been a highly complex process. Microbiotaimbalance has been involved in many disorders including cancers. Tayyeb food is related to food safety and is vitalfor the protection of health. Diet may be used to target alterations of the microbiota to improve outcomes acrosscancer prevention, tumor development, and progression. The aim of this study is to investigate diet-inducedmicrobiota as a potential option for cancer treatment.Material and MethodsThis review article was performed within articles published at PubMed, Science Direct, Google Scholar, SID, andCochrane until October ۲۰۲۲. The keywords were cancer, diet, microbiota, and treatment. By searching thisdatabase; ۶۲ articles were found, ۱۹ of them by Reading titles and abstracts were removed. ۴۳ articles were selectedunder the inclusion criteria. All articles were chosen from English and Persian articles.FindingsFinally, ۴۳ articles were included in the study. Tayyeb food as a public health priority, was essential forenhancement of health and quality of life. The western diet decreased beneficial bacteria, such as Bifidobacteria andEubacteria, while potentially unhealthy bacteria, suchas Bacteroides and Clostridia, increased. Beta-glucan whichstimulated the growth and activity of the desired natural intestinal microbiota played a vital role in the properfunctioning of the gastrointestinal tract and preventing inflammation as well as diabetes, hypercholesterolemia,obesity, cardiovascular diseases, and cancer. Synbiotics combined with enteral nutrition could be a supportive caretreatment for prophylactic antibiotics in patients with cancer. Administration of Lactobacillus plantarum ۲۹۹v couldbe effective in the improvement of the quality of life of cancer patients receiving home enteral nutrition. Microbiotaenteralnutrition reduced insulin resistance, improved the immune status, and promoted postoperative recovery inpatients with gastrointestinal cancer. Gut microbiota fermented dietary fiber to generate short-chain fatty acids(SCFAs), such as acetate, butyrate, and propionate, which could modulate the pathophysiology of the tumorenvironment through various critical signaling pathways. A probiotic combination containing Bifidobacteriuminfantis, Lactobacillus acidophilus, Enterococcus faecalis, and Bacillus cereus enhanced the immune response ofpatients and reduced the severity of inflammation through modification of gut microbiota. Cost-effective advancesin the form of ready-to-use therapeutic foods (RUTF) offered solutions for children with cancer in low- and middleincomecountries (LMICs) by redressing imbalanced microbiota and improving nutritional status.ConclusionDiet-induced microbiota alterations are key modulators of tumor etiology, progression, and response to cancertherapy. Observing a diet that nurtures healthy gut microbiota is essential to human health and increases lifeexpectancy. However, need to be more research done on this topic.

کلیدواژه ها:

Microbiota ، diet ، cancer ، treatment