Soraya Shahrokh - Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Masoud Yavari - Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
SeyedMehdi Moosavizadeh - Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Heydar Afshar - Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Galavij Ghoseiri - Department of Plastic Surgery, School of Medicine, Panzdahe Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Nilofar Massoudi - Department of Anesthesiology, School of Medicine, Critical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background: The purpose of this study was to analyze the effects and results of dimethyl sulfoxide (DMSO) usage on viability and perfusion of local and regional flaps in rabbits, via this study we are going to conclude whether DMSO could be effective after flap operations in human or not.Materials and Methods: Local and regional DMSO spray was used on rabbit’s dorsum flaps immediately after the operation and once per day up to ۷ days post-op in ۱۴ rabbits, divided equally to control group (saline solution spray) or experiment group (DMSO spray). The results were compared ۳ and ۷ days after operations.Results: There were improved results attributed to the DMSO effects regarding flap survivalConclusion: We concluded that topical application of DMSO reduces skin flap ischemia in rabbits and we highly advise the use of it after operations in which skin flaps are created.

DMSO, Regional flap, Perfusion, Ischemia