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The Role of Connective Tissue Genomics in Ascending Aortic Dissection: A Marfan Syndrome Scenario

عنوان مقاله: The Role of Connective Tissue Genomics in Ascending Aortic Dissection: A Marfan Syndrome Scenario
شناسه ملی مقاله: JR_SBMU-4-3_005
منتشر شده در January در سال 1398
مشخصات نویسندگان مقاله:

Firoozeh Madadi - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Manouchehr Hekmat - Department of Cardiac Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Ansari Aval - Department of Cardiac Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abdolhamid Bagheri - Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Kamal Fani - Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Hosein Ghanbarpour - Anesthesiology Department, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

خلاصه مقاله:
Background: Aortic dissection is a rare yet life threating condition with some already discovered risk factors namely hypertension, connective tissue disorders such as Marfan syndrome (MFS), cocaine abuse and cigarette smoking.Case report: In this article we would like to present a case of MFS who presented with severe chest pain and undergone Bentall surgery due to aortic dissection and aneurysm.Conclusion: Although many risk factors and preventive measures are already investigated, there is no definite method to avoid its occurrence in genetically predisposed patients such as MFS. Patient-specific models utilizing embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) may offer some advantages.

کلمات کلیدی:
Aortic Dissection, Marfan Syndrome, Induced Pluripotent Stem Cell; Embryonic Stem Cell

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1547118/