COX-۲ Expression in Carcinoma of the Breast and Surrounding Non-neoplastic Breast Tissue

Background: Breast carcinoma is the most common malignant tumor andleading cause of cancer related death in women worldwide. Apart from traditionalmarkers, estrogen receptor, progesterone receptor and Her-۲neu, which areimportant for prognostication and staging purposes, a novel markercyclooxygenase-۲ (COX-۲) is being studied extensively. We intend to study thespectrum of COX-۲ expression in normal breast tissue, ductal carcinoma in situ(DCIS) adjacent to invasive cancer, and in invasive cancer and compare COX-۲expression with histological prognostic parameters and hormone receptor status.Methods: The present study is a prospective study that was conducted in thedepartment of Pathology, SGT Medical College and Hospital, Gurugram (۲۰۱۹-۲۰۲۰). Fifty patients, aged between ۲۱ and ۷۰, suffering from primary breastcancer constituted the study group. Various histological prognostic parameterswere assessed. Immunohistochemical profile of the tumor was assessed. COX-۲score was correlated with various clinicopathologic parameters.Results: Among the total of ۵۰ patients suffering from invasive breastcarcinoma, ۹۴ percent (۴۷/۵۰) of cases showed the same COX-۲ expression levelin normal breast epithelium and corresponding tumor areas and this correlationwas statistically significant. The correlation between the level of COX-۲expression in tumor and DCIS was highly significant.Conclusion: Inhibition of COX-۲ may represent a potential target forpreventing breast cancer oncogenesis and as an adjuvant treatment followingsurgery to reduce local recurrence.

کلیدواژه ها:

Autocrine effect ، breast Cancer ، carcinogenesis ، COX-۲ expression ، paracrine effect