Effect of sesamol on damaged peripheral nerves: Evaluation of functional, histological, molecular, and oxidative stress parameters
- سال انتشار: 1401
- محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 12، شماره: 6
- کد COI اختصاصی: JR_AJP-12-6_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 223
نویسندگان
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
Department of Physiology, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Department of Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
چکیده
Objective: Peripheral nerve injury is a clinical problem that may cause sensory and motor inabilities. Sesamol is an antioxidant that can help in repairing damaged central nervous system (CNS) and other organs. The present study aimed to investigate whether the antioxidant effects of sesamol could improve the function, structure, and myelination in rats’ damaged peripheral nervous system (PNS).Materials and Methods: In this study, ۲۸ adult male Wistar rats were randomly divided into four groups. In the sham group, the sciatic nerve was exposed and restored to its place without inducing crush injury. The control received DMSO (solvent) and the two experimental groups received ۵۰ or ۱۰۰ mg/kg sesamol intraperitoneally for ۲۸ days after sciatic nerve crush injury, respectively. Next, sciatic function index (SFI), superoxide dismutase (SOD) activity, malondialdehyde (MDA) level, expression of nerve growth factor (NGF) and myelin protein zero (MPZ) proteins in the sciatic nerve, and histological indices of the sciatic nerve and gastrocnemius muscle were evaluated. Results: The results showed that sesamol reduced oxidative stress parameters, increased expression of NGF and MPZ proteins, and improved function and regeneration of the damaged sciatic nerve. Furthermore, a significant regeneration was observed in the gastrocnemius muscle after treatment with sesamol. Although administration of both doses of sesamol was useful, the ۱۰۰ mg/kg dose was more effective than the ۵۰ mg/kg one.Conclusion: The results suggest that sesamol may be effective in improving damaged peripheral nerves in rats by reducing oxidative stress and increasing the expression of NGF and MPZ proteins.کلیدواژه ها
Nerve growth factor, MPZ protein, Oxidative stress, Peripheral nerve injuries, Regeneration, Sesamolاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.