Protection of Calves Against Cryptosporidiosis by Hyperimmunization of Pregnant Cattle Colostrum using Oocyst Whole Antigens
- سال انتشار: 1401
- محل انتشار: فصلنامه طب دامی ایران، دوره: 16، شماره: 4
- کد COI اختصاصی: JR_IJVM-16-4_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 180
نویسندگان
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Parasitology, Faculty of Veterinary Medicine, University Of Tehran, Tehran, Iran
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Parasitology, Iranian Research Center of Ticks and Tick-borne Diseases, Faculty of Veterinary Medicine, University of Tehran,
چکیده
BACKGROUND: Cryptosporidium parvum is a coccidian parasite with worldwide distribution. OBJECTIVES: It is considered one of the most important causes of diarrhea in many vertebrate species and im-munocompromised humans. Due to the lack of effective treatment of cryptosporidiosis, protection strategy against this species can be focused on encouraging the immune system through vaccine development. METHODS: For this aim, we prepared oocysts lysate as a whole antigen vaccine candidate (۴۲۰ μg) and immun-ized ۳ pregnant cows ۴ times every ۲ weeks from ۷۰ days to parturition. As a control group, ۳ unimmunized pregnant cows were used. After parturition, each calf was fed with colostrum of his dam and challenged at ۱۲h of age with ۱×۱۰۷C. parvum oocysts. RESULTS: In contrast to the test group, the calves in the control group developed severe watery diarrhea with excretion of oocysts from ۴ days post-infection. The calves in the test group, which received the hyperimmune colostrum, showed no clinical signs and a significant reduction in oocysts excretion. CONCLUSIONS: The whole antigen prepared from oocysts of C. parvum can be considered a suitable candidate for immunizing pregnant cows producing hyperimmune colostrum.کلیدواژه ها
Cryptosporidium parvum, Hyperimmune colostrum, Immunization, Oocyst whole antigen, Pas-sive vaccineاطلاعات بیشتر در مورد COI
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