Application of Chitosan-Silver Nanoparticle as TheranosticAgents

Background and Aim : The term Theraryostic was first created in ۲۰۰۲ by, John Funkrouser,president of the Farmanic company while defining his company's business strategy for diagnosticdevelopment and its direct relevance with personalized therapy. He defines the diagnosis as "theability to define the state of the disease" and theranostics as "the ability to influence therapy ortreatment with the diagnosis of disease". One of the important components that must be consideredfor the development of a nano-theranostics system is the design of a nanocarrier or nano-platformthat can play an effective role in the theranostics system. Biosynthesized silver nanoparticles withtheranostics properties have anticancer applications, targeted drug delivery, and bioimaging.Polymeric nanoparticles are another category of nanocarriers that have therapeutic and diagnosticapplications. Chitosan (CS), a common cationic polysaccharide, is studied as a hopeful carrier inpharmaceutical and food industries for the improvement of delivery systems, due to its features ofbiodegradability, biocompatibility, and low toxicity. This review examines a new treatmentmethod called theranostics based on the natural polymer chitosan and silver metal nanoparticles.Methods : In order to select the articles, the papers of the years ۲۰۱۱-۲۰۱۹ were examined in theGoogle Scholar, PubMed, and Scopus databases with the keywords of theranostics, Agnanoparticles,and Chitosan. Information extraction from basic studies has been done. Thekeywords were selected by the MeSH browser.Results : In general, it can be said that the primary choice of scientists for the development of newmedicinal agents are natural polymers due to the mentioned advantages. Therefore, if we focus ona natural polymer and a metal nanoparticle such as gold, silver, copper, zinc, and titanium we canrefer to them as new nano theranostics agents with higher activity and higher diagnostic properties,and ultimately lower adverse effects. Chitosan-silver nanoparticles have also been used forinhibition of bacterial growth, tissue regeneration process, wound healing process, etc.Conclusion : The design of a nano-platform-based chitosan and silver nanoparticles has played aneffective role as a wound healer, antibacterial and effective drug delivery system.

کلیدواژه ها:

Theranostics ، Silver nanoparticles ، Chitosan (CS)