The Screening of Rubella Virus, Cytomegalovirus, Hepatitis BVirus, and Toxoplasma gondii Antibodies in Prepregnancy andReproductive-Age Women in Tabriz, Iran

Background and Aim : The organisms of Toxoplasma gondii, Rubella virus, Cytomegalovirus,and Herpes simplex virus as an acronym of TORCH are major pathogens in prepregnancy andreproductive-age women. These microorganisms are considered a serious problem and cause ۲-۳% of all birth defects in the fetus. Our study was aimed at screening the seroprevalence of TORCHantibodies among prepregnancy and reproductive-age women in Tabriz, Iran.Methods : This study was carried out in ۲۷۲۶ prepregnancy and reproductive-age women, whowere referred to the laboratory for prenatal TORCH screening. To detect the presence of IgG, IgMantibodies and Hepatitis B surface antigen against these microorganisms were carried out using achemiluminescence immunoassay analyzer (CLIA).Results : In the current study, the rates of anti-Toxoplasma gondii IgG, anti-Rubella virus IgG,and anti-Cytomegalovirus IgG were found in ۷۲۲ cases (۲۶.۵%), ۲۵۷۹ cases (۹۴.۶%۰), and ۲۷۱۸cases (۹۹.۷%), respectively. Moreover, the rates of anti-Toxoplasma gondii IgM, anti-Rubellavirus IgM, and antiCytomegalovirus IgM were discovered in ۱۰ cases (۰.۴%), ۱۳ cases (۰.۵%),and ۱۶ cases (۰.۶%), respectively. The Hepatitis B surface antigen was found in ۳۲ cases (۱.۲%).The dissemination of positive TORCH in various ages was different (P < ۰:۰۵).Conclusion : In our study, the seroprevalence of acute TORCH infections was relatively low. Dueto the probability of vertical transmission to the fetus during pregnancy and the unpleasantcomplication of these pathogens, it is essential to be screened for detection of specific IgG andIgM antibodies in reproductive ages.

کلیدواژه ها:

Rubella Virus ، Cytomegalovirus ، Hepatitis B Virus ، and Toxoplasma gondii