Background and Aim : The use of herbal medicines has a long history. Today, due to theresistance of microorganisms to antibiotics and antimicrobial substances, herbal medicines haveattracted attention due to their significant antimicrobial effects and low toxicity. This study aimsto systematically review the antimicrobial effects of different plant extracts (Scrophularia striata)as possible candidates for treating infectious diseases.Methods : The present study is a review study by searching reputable scientific databases such asPubMed, Google Scholar, Scopus, and Web of Science from ۲۰۰۰ to ۲۰۲۲ using the keywordsAntimicrobial, Scrophularia striata, Medicinal herbal, Infectious diseases the latest informationobtained.Results : In this study, ۴۰ articles were found and reviewed. The components used for theantimicrobial properties of this plant were root, seed, fruit, aerial parts, flowers, leaves, branches,and plant oil. The extracts used included water, hydro-alcoholic, ethanol, methanol, ethyl acetate,and chloroform. This plant had high inhibition activity and a lethal effect on gram-positive andgram-negative bacteria of ATCC strains, hospital and resistant strains Therefore, in addition toantibacterial effects, antiparasitic and antifungal effects were also observed on Leishmania majorand Candida albicans. The aerial parts of the plant were the most used and the most effectiveantimicrobial extract among the ethanol and methanol extracts.Conclusion : Due to the increasing antibiotic resistance in bacteria as well as the high toxicity ofchemical drugs and their side effects like high mortality in patients. The use of medicinal plants isrecommended. One of these plants is Scrophularia striata, which due to its effective antimicrobialsubstances, including Quercetin, Isorhamnetin-۳-O-rutinoside, and Nepitrin and having much lesstoxicity is recommended for clinical trials as a possible drug candidate in the treatment of patientswith various infectious diseases.