The Role of Viruses in Preventing Anoikis and Tumor Spread

Background and Aim : A specific type of programmed cell death called anoikis occurs whencells are severed from the extracellular matrix. Most cancer cells obstruct anoikis from spreadingby metastasis. One factor contributing to the resistance of cancer cells to anoikis is viral infections.This article focuses on how cancer-causing viruses help cancer cells prevent anoikis.Methods : Web of Science, PubMed, Scopus, and Science Direct databases were evaluatedscreening literature published online for factors in the resistance of viruses in anoikis. Articlesfrom the start to March ۲۰۲۱ were searched, and the search was only conducted in English. Theliterature was searched by using following key words: oncogenes, anoikis, programmed cell death,metastasis, and cancer.Results : Oncovirus resistance to anoikis is a powerful method by which virus-infected cancercells can colonize new places, disseminate to other organs, and endure. Consequently, viruses canquickly spread throughout the body, and healthy, normal cells can also catch an infection in thisway.Conclusion : For appropriate cell proliferation and tissue homeostasis, proper cell-ECMinteractions are required. When these relationships are disrupted, a process called anoikis, a typeof cell death, occurs, which allows cancer-causing viruses to live, migrate to other organs, andinfiltrate infected cancer cells. New areas are where the virus is active. Consequently, viruses canquickly spread throughout the body, and healthy, normal cells can also catch an infection in thisway. Identifying effective therapeutic platforms for treating virus-related malignancies may beaided by future research to acquire an excellent knowledge of how cancer-causing viruses alteranoikis inhibition.

کلیدواژه ها:

Carcinogenic viruses ، Anvikiz ، Planned cell death ، Metastasis ، Cancer