The use of actinomycetes in the production of secondarymetabolites, including antibiotics, in dealing with MRSA strains

Background and Aim : Staphylococcus aureus is one of the earliest bacteria detected in infants,children and adults with cystic fibrosis (CF). The rise of methicillin resistant S. aureus (MRSA) inthe last ten years has caused a lot of attention to this organism. The most important feature ofmicrobial bioactive compounds are that they have specific microbial producers, their diversebioactivities and their unique chemical structure. This review trys to check anti methicillin resistantof S. aureus activity of actinomycetes isolated from soil and fresh water, because MRSA is a majorhealth concern, as it causes numerous infections in both health care facilities and communities.Methods : According to published papers, scientists working on actinomycetes have used a nearlyidentical method, first collecting samples from different sources, mostly soil, at different depthsand distances, and mixing them with different compounds to make Use different jobs.Results : That most actinomycetes are Mesophile with an optimum growth temperature of ۳۰°C.The factors that affect the activity of actinomycetes in the production of secondary metabolites aretemperature, pH, concentration of sodium chloride salt (NaCl), carbon source, nitrogen source andthe best media for the growth of actinomycetes.Conclusion : During research, it has been shown that actinomycetes found in water and sea havebetter antimicrobial activity against pathogenic bacteria, including MRSA strains, Also, marineactinomycetes in lower concentrations inhibit the activity and growth of pathogenic bacteria.

کلیدواژه ها:

Actinomycetes ، Staphylococcus aureus ، MRSA ، CF ، secondary metabolites