Human adenovirus ۶ identification in tonsillar tissue ofchildren with tonsillar hypertrophy

سال انتشار: 1401
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 82

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شناسه ملی سند علمی:

MEDISM23_545

تاریخ نمایه سازی: 16 مهر 1401

چکیده مقاله:

Background and Aim : Tonsillar hypertrophy is a common condition in children that itspathogenesis has not been fully understood. The possible role of respiratory viral infection intonsillar hypertrophy is still under investigation. Human Adenovirus (HAdV) is one of theprobable candidates, which might be involved in inducing cell growth and apoptosis inhibition,leading to a tonsillar hypertrophy induction. This study aimed to estimate the rate of HAdVgenome detection, species, and types identification in tonsils of children aged ۱۵ years and youngerwith tonsillar hypertrophy.Methods : Nested PCR was performed on ۵۰ tonsil tissues from children undergoingtonsillectomies. Subsequently, Sanger sequencing was performed and phylogenetic tree wasdrawn.Results : HAdV genome was detected in ۱۶ (۳۲%) tissue samples in which HAdV-C۶ (۳۱.۳%,۵/۱۶) was identified as the predominant type, followed by HAdV-C۱ (۲۵%, ۴/۱۶), HAdV-C۵(۱۸.۷%, ۳/۱۶), HAdV-C۲ (۱۲.۵%, ۲/۱۶) and HAdV-B۷ (۱۲.۵%, ۲/۱۶).Conclusion : This study was consistent with other studies that reported HAdV-C (۸۷.۵%) aspredominant species in tonsil tissues. Interestingly, in this study HAdV-C۶ was the most commonidentified type with the potency of latency in children diagnosed with tonsillar hypertrophy. Thistype of adenovirus mostly causes asymptomatic infection which results in missing this type byscreening symptomatic patients. In order to achieve a better understanding of HAdVs role intonsillar hypertrophy pathogenesis more studies should be done.

نویسندگان

Zahra Heydarifard

Department of Virology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Vahid Salimi

Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Farshid Achak

Department of Otolaryngology, Marvasti hospital, Tehran University of Medical Sciences, Tehran, Iran

Sevrin Zadheidar

Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Kaveh Sadeghi

Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Mir Saeed Yekaninejad

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran