Prevotella As Next Generation Probiotic

Background and Aim : It is well-known that the human gut harbors millions of bacteria and theirmetabolic potential is immense. Dietary fiber in the human diet is the main source of accessiblecarbohydrate substrates for the gut microbiota, hence, using dietary manipulation of gut microbiotato increase the relative number of probiotic bacteria could contribute to the well-being of the host.The Dipeptidyl peptidase-۴ (DPP-۴) activity influences metabolic, behavioral and intestinaldisorders through the cleavage of key hormones and peptides. Some studies describe the existenceof human DPP-۴ homologs in commensal bacteria, for instance in Prevotella or Lactobacillus.Methods : Probiotic bacteria protect humans from pathogens through a process known ascolonization resistance.Colonization resistance refers to the mechanism used by microbiota that isalready present in the gut to maintain their presence, thereby avoiding colonization of the sameintestinal sites by pathogens. In the absence of antibiotics, or under healthy conditions, themicrobiota can effectively inhibit colonization and overgrowth of invading microbes associatedwith inflammation via specific interactions between the mucosal immune system and themicrobiota. As DPP-۴ plays a substantial role in the immune system, particularly in T cell function,DPP-۴ has been investigated as a possible target for treating autoimmune diseases includinginflammatory bowel disease.Results : Different studies have shown that Prevotella is a common microbial genus in individualswith a plant-based diet (high in fiber, and low in fats and protein), while an increase in Bacteroidesis common in individuals with a Western diet (low in fiber, and high in fats and protein).Growthof Prevotella spp. has also been found to be promoted by barley supplementation in healthyindividuals and co-occurred with improved glucose metabolism. A recent human interventionstudy investigating barley as a prebiotic has also shown that a higher Prevotella/Bacteroides ratiomay be beneficial to cardiometabolic regulation and The functions of the DPP-۴-like homologexpressed in the gut microbiota could influence dietary protein digestion and thereby contribute tothe change in the host response toward these peptides.Conclusion : This finding indicates that the genus Prevotella plays a role in the dietary-inducedimprovement in glucose metabolism in observed individuals ˓and it can be a potential probiotic,addressing glucose management

کلیدواژه ها:

Prevotella ، Probiotics ، Dipeptidyl peptidase-۴ ، intestinal disorders