Stem cell therapy for COVID۱۹: The impact of coronavirusinfection on recipients of hematopoietic stem cell transplantation

Background and Aim : coronavirus disease ۲۰۱۹ (COVID-۱۹) caused by severe acute respiratorysyndrome coronavirus has become a global pandemic. COVID-۱۹ can lead to a cytokine stormand patients usually have early respiratory signs and further secondary infections, which can befatal. COVID-۱۹ has entered an emergency phase, but there are still no specific effective drugs forthis disease. In the past, many researchers have conducted various studies on theimmunomodulatory properties of stem cells. This property of stem cells led them to modulate theimmune system of autoimmune diseases like diabetes, multiple sclerosis, and Parkinson's. Becauseof their immunomodulatory properties, stem cell-based therapy employing mesenchymal orhematopoietic stem cells may be a viable alternative treatment option in some patients. By primingthe immune system and providing cytokines, chemokines, and growth factors, stem cells can beemployed to build a long-term regenerative and protective response. This review addresses thelatest trends and rapid progress in stem cell treatment for Acute Respiratory Distress Syndrome(ARDS) following COVID-۱۹.Methods : A literature search was performed on PubMed, Medline, Google Scholar, Scopus andClinical trials. for studies reporting the efficacy/effectiveness of stem cells in patients withCOVID-۱۹.Results : Mesenchymal stem cells may help to restore the lung microenvironment, preservealveolar epithelial cells, prevent lung fibrosis, and treat pulmonary dysfunction that is caused byCOVID-۱۹ associated pneumonia. Mesenchymal Mstem cells therapy may suppress aggressiveinflammatory reactions and increase endogenous restoration by improving the pulmonarymicroenvironment. Furthermore, clinical evidence suggests that intravenous injection ofmesenchymal stem cells may radically reduce lung tissue damage in COVID-۱۹ patients. With theadvancement of research involving mesenchymal stem cells for the treatment of COVID-۱۹,mesenchymal stem cells therapy may be the main strategy for reducing the recent pandemic. Theanalysis showed that stem cell therapy could significantly reduce the mortality rate and morbidityin patients with COVID-۱۹.Conclusion : The present study suggests that stem cell therapy has a remarkable effect on reducingmortality and morbidity of patients with COVID-۱۹. Further large-scale studies are needed toapprove these results. Defining a protocol for stem cell therapy in patients with COVID-۱۹ canlead to achieving the best clinical outcomes.

کلیدواژه ها:

COVID-۱۹ ، Mesenchymal stem cells ، Pandemic ، Stem cell therapy