Effect of Hydroalcoholic and Aqueous Extracts of CarumCopticum on Escherichia Coli Strains in comparison with Gentamicin
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی میکروب شناسی ایران
- کد COI اختصاصی: MEDISM23_422
- زبان مقاله: انگلیسی
- تعداد مشاهده: 192
نویسندگان
PhD Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
PhD Infection Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
MD Student Research Center, Babol Medical University, Babol, Iran
چکیده
Background and Aim : In Persian medicine Ajwain (Carum Copticum (L.)) is recommended forthe treatment of some infections. Due to bacterial resistance to antibiotics, a new antibacterialagent is essential. In this research, bactericidal and bacteriostatic effects of hydroalcoholic andaqueous extracts of Ajwain on E. coli was investigated.Methods : In this in -vitro study a standard sample and ۳۰ clinical isolates of urine culture ofchildren with urinary tract infection from Amirkola Pediatric Hospital in Babol and were used.Antibacterial effects of ۲ groups including hydroalcoholic and aqueous extracts of Ajwain bymeasuring the diameter of the inhibition zone using disc diffusion (concentrations ۱۶, ۳۲, ۶۴, ۱۲۸,۲۵۶ and ۵۱۲ mg /disc) and Minimum Bactericidal Concentration (MBC) and determination ofMinimum Inhibitory Concentrations (MIC) with Microdilution method was compared withGentamicin (۳۰mg /disc) as a positive controlResults : Results: Regarding to the inhibition zone with Gentamicin at concentrations of ۶۴, ۱۲۸,۲۵۶, and ۵۱۲ mg/disc in standard and clinical samples, there was no significant difference.Gentamicin was significantly better at concentrations of ۱۶ and ۳۲. The extract of ۵۱۲ mg /disc(۱۲.۹۳±۲.۶۶) of hydroalcoholic extract of Carum Copticum was significantly better than ۲۵۶ mg/disc (۹.۵۳±۱) (p=۰.۰۰۲). The MIC and MBC for standard samples were ۴ and ۸, respectively, andfor clinical samples ۳.۸۳ ±۲.۳۶ and ۵.۸ mg / ml, respectively. aqueous extracts of Ajwain was notable to inhibit the growth of Escherichia coli .Conclusion : The Hydroalcoholic extract of Carum Copticum has bacteriostatic and bactericidaleffects on standard and clinical isolates of Escherichia coli.کلیدواژه ها
Anti -Bacterial Agents, Ajwain, Persian Medicineمقالات مرتبط جدید
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