The Impact of the Gut Microbiome on Toxigenic Bacteria

Background and Aim : A vast amount of evidence in recent decades has strongly indicated thathuman microbiota has vital function in the human condition by several mechanisms (۳, ۴). Inaddition, the microbiota can increase food energy extraction (۵), raise nutrient yield (۳),(۶) andchange the signaling of appetite (۷),(۸). Second, the human microbiota also develops a physicalobstacle by production of antimicrobials and the competitive elimination which help to defendthehost against external pathogens (۹)–(۱۰) This article is based on how anti-infectious defensemechanisms interfere with host-microbiota interactions and also elucidate the direct conflictbetween pathogens or commensals in the bodyMethods : The gut microbiota cells outnumber the somatic cells ۱۰–۱۰۰ times, but most of themcan not be grown in vitro. Molecular technologies have shown that the healthy human floracomprises more than ۹۹.۱ percent of bacterial species and is primarily represented by four phyla,Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria.The interaction between the gutmicrobiota and the organism may be symbiotic, cooperative, or commensal, thus allowing forcolonization with protective species ("symbionts"), (۲۴)The organism avoids enteric pathogens viaan "intestinal barrier" consisting of three interdependent elements: the intestinal microbiota, thecontinuous intestinal epithelium covered by the mucus layer, and the mucosal immunityResults : Whenever antibiotics are used regardless of targeting, we have calculated the collateraleffects on the gut microbiome.Bacterial pathways or growth functions, biochemistry, andmetabolism have been conserved. .(۱۳۸) Intestinal microbiotaderived urinary biomarkers ofcolonization resistance in antibiotic-treated mice are identified in a targeted metabolomicsmethod.(۱۳۸) In comparison to antibiotic therapy, the elegance of CRISPR/Cas technologyinvolves the delivery of bacterial strain-specific gRNA, exploiting the CRISPR/Cas framework ofthe target bacteria for accurate targeted treatment.Conclusion : Many scientists believe that the human intestinal microbiome is a complexecological group that influences normal physiology and disease susceptibility through consensualmetabolism, immunology, and host interaction. In combination with animal studies, highefficiencysequence, and computational techniques, therapeutic products' efficacy and toxicity atthe population-level remained unclear. Although several studies have shown a higher prevalenceof food, nutrients, pharmacology [(۱۴۴, ۱۴۵) the impact of host genetic factors on intestinalmicrobiota cannot be ignored or excluded[۲۵]

کلیدواژه ها:

Health ، microbiota ، toxigenic ، Treatment