In-vitro activity of antibiotics combination againstcarbapenem resistant Acinetobacter baumannii

Background and Aim : The present study was performed to investigate in-vitro effect ofantimicrobial agent’s combination against carbapenem-resistant Acinetobacter baumannii.Methods : Ten carbapenem resistant A. baumannii isolates were collected from differentspecimens. The resistance to meropenem were detected by the phenotypic and PCR methods. Theantimicrobial effect of antimicrobial agents was determined by the micro broth dilution methodaccording to the CLSI guideline. To synergetic effects of the drugs combinations, the checkerboardassay was used for fractional inhibitory concentration (FIC) determinationResults : The highest synergic interaction was observed in colistin/meropenem andamikacin/meropenem (۸ of ۱۰ isolates), and the lowest synergic interaction was observed incolistin/amikacin and colistin/ciprofloxacin (۲ of ۱۰ isolates).Conclusion : Distinct and standard testing of inhibitory activity of the antimicrobial agent’scombination is required for treatment of high level resistant pathogens. Colistin/meropenem andamikacin/meropenem were more effective against carbapenem resistant A. baumannii.

کلیدواژه ها:

Acinetobacter baumannii ، Antimicrobial Combination ، Carbapenem-resistant