Synthesis and investigation of antibacterial carbon nitride

Background and Aim : Nosocomial infections have a high prevalence and are a serious problemfor health care centers and they impose a lot of costs on patients and health care centers every year.The emergence of multi-drug resistant microorganisms as a result of hospital infections andbacterial resistance to antibiotics, is one of the most important health problems around the worldand threatens human health in the modern era. Therefore, it is of great importance to develop anew strategy to inactivate bacteria. Graphite carbon nitride (g-C۳N۴) as a new class of twodimensionalnon-metallic semi-conducting nanomaterials whose structure is close to graphene interms of being planar has recently attracted the attention of many scientists. Our aim in this studyis to synthesize and investigate antibacterial properties. of Carbon nitride.Methods : For the synthesis of graphite carbon nitride, raw materials such as melamine aresubjected to heat treatment using a Muffle furnace. SEM, EDS, MAP, XRD, UV-VIS, FTIRcharacterization tests are used to check carbon nitride characteristics such as particle size andstructure, and to evaluate the number of Gram-positive and negative bacteria colonies or thediameter of the non-growth halo in order to determine the properties. Antibacterial MIC and MBCtests are usedResults : Characterization analyzes were performed to confirm the particle size and structure.Also, the colony count results of the experiment showed that the colony density of both bacterialstrains decreased after exposure to the nanomaterial. In addition, the minimum bacterial inhibitoryconcentration (MIC) and the minimum lethal concentration (MBC) of graphite carbon nitride foreach of the bacteria. It was equal to ۲۵ micrograms per milliliter.Conclusion : Graphite carbon nitride nanomaterial, due to their unique physical, chemical andmechanical properties, especially the high specific surface area and the very sharp edges of thesetwo-dimensional materials that can damage the outer membrane of bacteria and because ofbiocompatibility High, low cost and quick and easy synthesis are more important compared toother nanomaterials.

کلیدواژه ها:

Antibiotic Resistance ، Carbon nitride ، Antibacterial property