Determination of Colistin-Resistance Pseudomonas aeruginosaIsolates from Bovine Mastitis in Mashhad, Iran
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی میکروب شناسی ایران
- کد COI اختصاصی: MEDISM23_157
- زبان مقاله: انگلیسی
- تعداد مشاهده: 69
نویسندگان
Department of Bacteriology and Virology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
چکیده
Background and Aim : In the dairy industry, bovine mastitis (BVM) is indicated as a significantconcerning result of economic loss worldwide. Bacterial infections are introduced as the mainreason for BVM; subsequently, antibiotic therapy has been propounded as the first line of combatin mastitis cases because antibiotic residue in milk will develop diminishing antibiotic resistanceto the environment. P. aeruginosa, a non-fermentative gram-negative rod-shaped bacterium, iswidely associated with several infections, specially BVM. Also, P. aeruginosa is listed as a criticalpriority pathogen by the World Health Organization due to emerging multi-, extended- and pandrugresistance P. aeruginosa isolates. The present study was performed to aim to assess theantimicrobial susceptibility pattern among phenotypic resistant P. aeruginosa isolates from clinicalmastitis from Mashhad, northeast Iran.Methods : The current study was conducted on a collection of P. aeruginosa isolates from clinicalmastitis cases kept at the Microbiology laboratory, faculty of veterinary, Ferdowsi University ofMashhad. A total of ۵۰ P. aeruginosa isolates from clinical mastitis cases were subjected in thecurrent study. The Kirby-Bauer method was used to determine all isolates' antimicrobialsusceptibility patterns. The colistin broth disc elution method (CBDE) was used as CLSI (۲۰۲۲)recommended demonstrating the colistin-resistant isolates.Results : The antimicrobial susceptibility testing has revealed the highest resistance againstmeropenem ۴۰ isolates (۸۰%); however, aztreonam has shown a significant sensitivity (۱۰۰%).Also, all isolates were sensitive to tobramycin and gentamycin. The CBDE test has determined ۳colistin-resistance isolates.Conclusion : The emergence of colistin-resistance P. aeruginosa is a global issue that indicatesantimicrobial stewardship is necessary to manage increasing antimicrobial resistance.کلیدواژه ها
Bovine mastitis, Colistin, P. aeruginosaاطلاعات بیشتر در مورد COI
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