Evaluation of the association of XRCC۷ rs۷۰۰۳۹۰۸ gene polymorphism in children with lymphoid cancer

Background: Today, cancers are one of the leading causes of death in children, the mostcommon type of which is leukemia. Acute lymphoid leukemia (ALL) was formed in the bonemarrow due to the high accumulation of underdeveloped lymphocytes. The XRCC۷ genome isone of the genes in the DSB repair system and also, its repair pathway is NHEJ. The aim of thisstudy was to investigate the XRCC۷ gene polymorphism in children with acute lymphoid cancer.Materials and Methods: XRCC۷ genome polymorphism have compared between ۷۰ childrenand adolescents under ۱۸ years of age with lymphoid leukemia and ۱۴۰ healthy children andadolescents under ۱۸ years of age using RFLP and PCR methods. And statistical analysis hasperformed using SPSS۲۵ software, too.Results: The findings show that among the blood groups with ALL, the O+ blood group had thehighest frequency and out of ۷۰ patients, ۳۳% had the O+ blood group. The frequency of TT, TG,GG genotypes in two groups of patients were ۱۰%, ۴۲% and ۴۸%, respectively, and in thehealthy group was ۶۳%, ۲۲% and ۱۵%. According to (P = ۰.۰۰۱), genotypic distribution in thispolymorphism shows a significant relationship with ALL disease.Conclusion: Comparative analysis done on XRCC۷ gene polymorphism at rs۷۰۰۳۹۰۸ positionin two healthy and affected groups indicates that there was a significant relationship betweenXRCC۷ gene polymorphism and lymphoid cancer in GT genotype. Also, the results of some ofthe studied factors such as parental addiction to smoking, gender and family history of thedisease indicate that the presence of these factors is significantly associated with the risk ofhaving a variety of leukemias, including lymphoid cancer.

کلیدواژه ها:

children ، leukemia ، polymorphism