The effect of Crocin on breast cancer

  • سال انتشار: 1400
  • محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
  • کد COI اختصاصی: CHGGE01_298
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 151
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نویسندگان

Yaser Asefi

Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran

چکیده

Backgrounds: Cancers are one of the leading causes of death in the world. DNA damage causedby radioactivity is significantly involved in the development of cancers, and the factors thatreduce their formation should reduce the risk of cancer. The role of antioxidants in theprevention and treatment of cancers has been reported by many studies. The aim of this studywas to evaluate the effect of Crocin on breast cancer cell line.Materials and Methods: Breast cell line was treated with different concentrations of Crocin.The effect of Crocin on cell mortality was measured by MTT method. In this test, cells werecounted with trypan blue and ۱۰,۰۰۰ cells were cultured in ۹۶-well plates and the cells weretreated for ۴۸ hours.Results: The test results were evaluated by MTT test. The treated cells had a higher mortalityrate than the control group. This mortality was dose-dependent, which increased cell death withincreasing dose. IC۵۰ for breast cancer ۵۱ μg / ml was calculated.Conclusion: MTT test results showed that Crocin dose had a significant effect on cancer celldeath and ۷۲ hours of treatment had the best results (p < ۰.۰۵). The effect of Crocin on cancer celldeath was due to its antioxidant effect, which was in line with other researchers.

کلیدواژه ها

Antioxidant, Crocin, Breast cancer, MTT

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