Bioinformatics analysis of Iranian medicinal plants in the treatment of brucellosis

  • سال انتشار: 1400
  • محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
  • کد COI اختصاصی: CHGGE01_294
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 136
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نویسندگان

Fereshteh Akbari

Islamic Azad University, Tehran Medical Branch, Tehran, Iran

چکیده

Backgrounds: Brucellosis is a chronic and infectious disease common to humans and animalscaused by bacteria of the genus Brucella, which are gram-negative and aerobic microorganisms.Currently, six species of Brucella are known: B. abortus, B. melitensis, B. suis, B. neotoma, B.ovis and B. canis. B. melitensis strain, which is also contagious to humans, is the most commonin Iran .Due to the fact that wild pigs are not studied and vaccinated in Iran, and these animalslive very close to rural areas, it can be said that controlling the disease through vaccination isalmost impossible. Also, apart from the previously known ways of spreading the disease,poachers can cause the spread of the disease in humans and livestock.Materials and Methods: After receiving the structure of B. melitensis strain catalase proteinand its energy minimized, ۷۰ ligands from ۱۲ native Iranian medicinal plants were docked withBrucella bacterial protein catalase by Pyrex software in Autodac ۴.۲.Results: The best docking results were related to a ligand called Abietic acid in Ferula assafoetidawith binding energy of -۱۰.۱۱ and Ki = ۳۸.۷۳ nM and also Stigmasterol in Pimpinellaanisum with binding energy of -۷۲.۷۲ and Ki = ۷۴.۸۶ nM.Conclusion: Due to the importance and prevalence of brucellosis in Iran and also the existenceof deficiencies in animal vaccination in this disease and its non-eradication, the capacity ofIranian medicinal plants that are available can be used to treat patients and treat animals.

کلیدواژه ها

Brucellosis, Treatment, Catalase, Iranian medicinal plants

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