The Impact of Single-Nucleotide Polymorphisms rs۸۵۲۹۷۷ of NR۳C۱ Gene on Depression in North of Iran

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 52

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شناسه ملی سند علمی:

CHGGE01_224

تاریخ نمایه سازی: 13 مهر 1401

چکیده مقاله:

Backgrounds: Depression (major depressive disorder) is a common and serious medical illnessthat negatively affects how you feel the way you think and how you act. This disease isconsidered to be the most common psychiatric/psychological disorder and is characterized bycomplex and very diverse physical, mental and behavioral symptoms in individuals (especially inthe adult and elderly age groups). The biological mechanisms involved in the relationshipbetween immune system activation and depression can be influenced by the underlying geneticvulnerability. Various studies have shown increased levels of inflammatory cytokines and theirreceptors in the peripheral blood and cerebrospinal fluid (CFS) of patients with major depression.Materials and Methods: In this study, we are investigating the effect of single nucleotidepolymorphisms; rs۸۵۲۹۷۷ of NR۳C۱ genes on the depression, we are sampling and genotyping۶۱ patients with depression using T-ARMS PCR with the statistically interpreting of results byMedCalc software.Results: Disruption of the glucocorticoid signaling pathway leads to depression. Three SNPs ofthe NR۳C۱ gene (rs۲۵۸۷۵۰, rs۶۱۸۸ and rs۸۵۲۹۷۷) showed significant relationships with theexpression of a large number of genes that could be candidates for genetic modifiers ofregulatory pathways associated with chronic fatigue. In this study, after receiving the statisticalresults, it will be investigated what effect the single nucleotide polymorphisms will have ondepression.Conclusion: NR۳C۱ gene encodes the glucocorticoid receptor. Mutations in the NR۳C۱ gene areassociated with general glucocorticoid resistance. Intermittent splicing of this gene results intranscript variants that encode similar or different isoforms.

نویسندگان

Tahereh Haghzad

Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Farzam Ajamian

Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Somayeh Shokrgozar

Psychiatry Department, Shafa Educational – Remedial Hospital, Guilan University of Medical Sciences, Rasht, Iran