The Role of ccr۵ Receptor in Expression of neat-۱ in Breast Cancer Patients with Positive HIV
- سال انتشار: 1400
- محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
- کد COI اختصاصی: CHGGE01_171
- زبان مقاله: انگلیسی
- تعداد مشاهده: 84
نویسندگان
Zist Fanavari Novin Biotechnology Department, State Technical and Vocational Training Organization, Isfahan, Iran
Zist Fanavari Novin Biotechnology Department, State Technical and Vocational Training Organization, Isfahan, Iran
Zist Fanavari Novin Biotechnology Department, State Technical and Vocational Training Organization, Isfahan, Iran
Zist Fanavari Novin Biotechnology Department, State Technical and Vocational Training Organization, Isfahan, Iran
چکیده
Backgrounds: Breast cancer is one of the leading causes of cancer-related death in womenworldwide, and its prevalence is rising over time. By now, a few studies have reported on theaction of NEAT-۱ in breast cancer. Most studies focus on its role as a hypoxia-induced lncRNAthat leads to accelerated cellular proliferation and tumorigenesis. NEAT-۱ was found to be oneof the several lncRNAs whose expression is altered by HIV-۱ infection. This gene generates along non-coding RNA (lncRNA) from the multiple endocrine neoplasia loci. This lncRNA iskept in the nucleus and serves as a structural component of the paraspeckle sub-organelles. It hasthe potential to act as a transcriptional regulator for a wide range of genres, including someinvolved in cancer progression.Materials and Methods: In this study, the roles of the CCL۵/Chemokine Receptor ۵ (CCR۵)axis and NEAT-۱ were discussed in promoting breast cancer and progression in HIV-positivepatients to validate the related previous findings. For this purpose, the CCR۵ gene function wasstudied through LncRNA Disease and DAVID. Genecards database described a gene involved inHIV.Results: The bioinformatics analysis revealed that CCR۵ plays a role in HIV infection, whichmay contribute to the development of breast cancer by causing lncRNA NEAT-۱ overexpression.Conclusion: All things considered, it seems reasonable to assume that CCR۵ is associated withHIV infection and breast cancer. As a result, suppressing lncRNA NEAT-۱ in breast cancer celllines may result in lower proliferation and metastasis.کلیدواژه ها
CCR۵, LncRNA-NEAT۱, Breast cancer, HIV-۱اطلاعات بیشتر در مورد COI
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