Prevalence of Chromosomal abnormalities in cytogenetic findings of patients studied in Golestan province
محل انتشار: کنفرانس بین المللی ژنتیک و ژنومیکس انسانی
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 55
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شناسه ملی سند علمی:
CHGGE01_156
تاریخ نمایه سازی: 13 مهر 1401
چکیده مقاله:
Backgrounds: Chromosomal abnormalities, numerical and structural, act as the main reasons inmany health conditions resulting in developmental problems. However, these are molecular andmolecular-Cytogenetics platforms that become increasingly popular and practical for CAdetection; sophistically, karyotyping, the conventional test for CA, still acts as the most commontest for CA in many saturations. Cytogenetics findings observed in patients referred for CA studyhave been reported in this study.Materials and Methods: Blood samples from ۳۰۲ patients were tested by conventional GbandingKaryotype tests. Separately, two different expert lab technicians analyzed andinterpreted all the spreads, and finally, all the abnormal results were recorded.Results: Down syndrome, the most frequent finding, was observed in ۱۴% abnormal cases;Turner syndrome was ۱۲%, while Klinefelter syndrome was seen in ۶% cases. Isochromosome Xand DSD were seen ۴%, and Inversion was in ۱۴% of cases.Conclusion: Numerical aneuploidy abnormalities are the most common CA between the patientsattended to Kavosh Medical Genetics Laboratory of Golestan province from April ۲۰۱۶ toNovember ۲۰۱۸.
کلیدواژه ها:
نویسندگان
Mana Zakeri
Department of Biology, Islamic Azad University, Tehran medical branch, Tehran, Iran