Evaluation of Lactate Dehydrogenase and Gamma Glutamyl Transferase Among Pregnant Women with Hypertensive Disorders and Their Association with Disease Severity in Jimma Medical Center, Ethiopia
- سال انتشار: 1401
- محل انتشار: فصلنامه زنان و مامایی و سرطانهای زنان، دوره: 7، شماره: 6
- کد COI اختصاصی: JR_JOGCR-7-6_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 118
نویسندگان
Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
Department of Biomedical Sciences, Institute of Health Sciences, Jimma University, Jimma, Ethiopia
Department of Biomedical Sciences, Institute of Health Sciences, Jimma University, Jimma, Ethiopia
Department of Biomedical Sciences, Institute of Health Sciences, Jimma University, Jimma, Ethiopia
Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia
چکیده
Background & Objective: Pregnancy-induced hypertensive disorders (PIHD) are the main reasons for maternal and perinatal mortality, as they complicate ۱۰% of pregnancies worldwide. Serum lactic acid dehydrogenase (LDH) and gamma-glutamyl transferase (GGT) are possible markers reflecting the occurrence of pregnancy-associated complications like preeclampsia and eclampsia. There is a paucity of data with conflicting results showing serum LDH and GGT on PIHD in Ethiopia. This investigation aimed to assess the serum LDH and GGT levels in pregnant women with PIHD along with their correlation with the severity of the disease at Jimma Medical Center (JMC), Ethiopia. Materials & Methods: This hospital-based comparative cross-sectional study was undertaken from August ۰۳ to September ۲۷, ۲۰۲۰, in JMC. A total of ۹۷ study participants were recruited. Serum GGT and LDH levels were determined using a fully automated Roche Cobas ۶۰۰۰ chemistry analyzer. The data were analyzed using SPSS ۲۵.۰. One-way ANOVA and independent samples t-test were employed to compare serum GGT and LDH levels with categories of PIHD. Results: The significantly highest mean serum levels of LDH (۵۸۰.۹±۱۹۳.۸ U/L) and GGT (۸۶.۱±۲۹.۲ U/L) were observed in eclamptic women compared to gestational hypertensive (۲۷۶.۷±۶۰.۷ and ۳۸.۳±۱۶.۹ U/L) and preeclamptic patients (۳۵۳±۱۳۲.۸ and ۴۸.۸±۲۹.۹ U/L), respectively. Both serum GGT and LDH levels were found to correlate with the severity of preeclampsia, respectively significantly. Conclusion: Serum LDH and GGT were found to be at the highest levels in eclamptic than preeclamptic and gestational hypertensive women. Blood pressure, gestational age, and severity of hypertensive disorders of pregnancy were predictor variables associated with serum GGT and LDH.کلیدواژه ها
Eclampsia, Ethiopia, GGT, LDH, Preëclampsiaاطلاعات بیشتر در مورد COI
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