Neural stem cells in epilepsy treatment

Epilepsy is a weakening and infirming disease that influences approximately ۵۰ millions of people worldwide with the highest prevalence in low-income countries. The epilepsies are a group of neurological disorders that are characterized by spontaneous recurrent seizures. The loss of neuronal cells or extreme electrical discharge in neural cells following injury results in recurrent seizure attacks. The treatment of temporal lobe epilepsy (TLE) caused by hippocampal sclerosis is one of the major challenges in thefield of regenerative medicine. In recent years, stem cell-based therapy as the novel therapeutic approach has been highlighted to manage, alleviate and even to stop theseizure attacks and hyperexcitability. Up to now, different stem cells have been applied to alleviate and rescue the cognitive deficits and neuropathological alterations in TLE using in -vitro and in-vivo assays. Considering the discovery of the neural stem cells in the mammalian brain, the hope has been raised in the TLE treatment. Seme areas inmammalian brain by the existence and activation of neural stem/progenitor cells (NSCs) to produce new neurons, have the partial self repair capacity. However, there is still no evidence that extensive spontaneous replacement of dead neurons by newly formed neurons leads to functional recovery in the damaged brain. Here we will discuss the effect of epilepsy on behavior of endogenous NSCs and reversely the potential of endogenous NSCs in epilepsy treatment and gifted NSCs which isolated from different parts of the brain and embryonic stem cell to stop the seizure attacks and epilepsy treatment.

کلیدواژه ها:

Neural Stem Cells ، Epilepsy ، Treatment.